endocrine workshop slides

ISRTP

ISRTP Workshop:
Conducting and Assessing the Results of Endocrine Screening
February 19 & 20, 2008

Lister Hill Center Auditorium
(NIH Building 38A)
Bethesda, MD

PROGRAM & SLIDES

FEBRUARY 19, 2008
8:00 - 9:00	Registration and Continental Breakfast
9:00 - 9:25	Introduction and Welcome Terry Quill MS, JD, Conference Chair (Quill Law Group LLC)
9:30 - 10:00	Presentation of the ISRTP International Achievement Award to Bernard A. Schwetz, D.V.M., Ph.D.
SESSION I – Background & Current Status of Endocrine Screening: EPA’s Endocrine Disruptor Screening Program (EDSP) Tier I
10:05 – 10:20	Introduction to Session I - "Historical Perspective of the Endocrine Disruption Issue, EDSTAC and Validation" Angelina Duggan, Ph.D., Session Chair, (Exponent)
10:20 - 10:50	“An Update on the Implementation of the EPA’s Endocrine Disruptor Screening Program” Gary Timm (US EPA)
10:55 - 11:10	Coffee Break
11:15 - 11:45	“Validation of Endocrine Screens: Status and Lessons Learned” J. Willie Owens, Ph.D. (Procter & Gamble)
11:50 - 12:45	Session I Panel Discussion: Angelina Duggan, Ph.D., Session Chair (Exponent) Jim Lamb, Ph.D. (The Weinberg Group) J. Willie Owens, Ph.D. (Procter & Gamble) Gary Timm (US EPA, OSCP)
12:45 - 1:55	Lunch Buffet (included with registration)
2:00 - 2:40	Keynote Presentation: “A Framework for Weight of Evidence: Application to Endocrine Effects and the Low-Dose Hypotheses” Lorenz Rhomberg, Ph.D. (Gradient Corporation)
SESSION II – Challenges Faced in Interpreting EDSP Assays & the Tier 1 Battery; Applying Weight of Evidence for Triggering Tier 2 Testing
2:45 - 3:00	Introduction to Session II Richard Becker, Ph.D., Session Chair (American Chemistry Council)
3:05 - 3:45	“General Principles and Challenges Interpreting EDSP Screening Assays Results” Sue Marty, Ph.D. (Dow)
3:45 - 4:00	Afternoon Break
4:00 - 4:35	“Applying Weight of Evidence to Screening Assay Results: When is Additional Testing Needed?” Steve Levine, Ph.D. (Monsanto)
4:40 - 5:00	“Overview of EPA’s Endocrine Research Program” Elaine Francis, Ph.D. (US EPA, ORD)
5:00 - 5:45	Session II - Panel Discussion: Rick Becker, Ph.D. (ACC), Elaine Francis, Ph.D. (US EPA), Steve Levine, Ph.D. (Monsanto), Sue Marty, Ph.D. (Dow) and L. Rhomberg, Ph.D. (Gradient)
5:45 - 7:00	Evening Reception (included with registration)
FEBRUARY 20, 2008
8:00 - 9:00	Continental Breakfast
9:00 - 9:10	Welcome and Announcements Terry Quill, MS, JD, Conference Chair (Quill Law Group LLC)
9:10 - 9:40	Keynote Presentation: “The Endocrine System: Overview and Some Issues to Consider in Endocrine Disruption” Ray Witorsch, Ph.D. (Medical College of Virginia)
SESSION III - Using the EDSP Screening Results in Risk Assessment
9:45 - 10:00	Introduction to Session III Bernard A. Schwetz, D.V.M., Ph.D., Session Chair
10:05 - 10:35	"Endocrine Modes of Action & Risk Assessment" Vicki Dellarco, Ph.D. (US EPA, OPP)
10:40 - 10:45	Coffee Break
10:50 - 11:20	“Cumulative Risk: The Case FOR an Estrogen Equivalents Approach” A. Kortenkamp, Ph.D. (University of London)
11:25 - 11:55	“Cumulative Risk: The Case AGAINST Estrogen Equivalents” Chris Borgert, Ph.D. (Applied Pharmacology and Toxicology)
12:00 - 12:20	Keynote Presentation: “Do All Roads Lead to Endocrine Disruption?” Gio Gori, D.Sc., MPH (The Health Policy Center)
12:20 - 1:20	Lunch Buffet (included with registration)
1:20 - 2:25	Session III - Panel Discussion: Bernard Schwetz, D.V.M., Ph.D., Chris Borgert, Ph.D. (Applied Pharmacology and Toxicology), Gio Gori, D.Sc., MPH (The Health Policy Center), Robert Golden, Ph.D. (ToxLogic) A Kortenkamp, Ph.D. (University of London), Ray Witorsch, Ph.D. (Medical College of Virginia)
SESSION IV- Implementation of EPA’s EDSP
2:30 - 3:00	“EPA’s Procedural Notice: What are the Legal and Regulatory Issues?” Terry Quill, MS, JD (Quill Law Group, LLC)
3:00 - 3:45	Perspectives of Stakeholders on Implementation of EPA’s EDSP Terry Quill, MS, JD (Quill Law Group, LLC) Sarah Brozena (American Chemistry Council) Susan Ferenc (Chemical Producers & Distributors Association) Patrick Guiney (S.C. Johnson & Son, Inc.) Ellen Mihaich (Environmental & Regulatory Resources LLC)
Conference Wrap-Up
3:50 - 4:00	Chris Borgert, Ph.D. (President, ISRTP)

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