ISRTP Annual Business Meeting Minutes
Office of Counsel Gary L. Yingling, Esq.
1900 K Street, NW
Washington, DC 20006
January 12, 1998
10:00 A.M. - 2:00 P.M. 

ATTENDEES: Drs. Brown, Carr, Chaisson, Domeyer, Fogleman, Frawley, Giovacchini, Gori, Keller, McEwen, Wilkinson; Messrs. Barnard, Heckman and Yingling; Ms. Sallie Carr; and the ISRTP International Achievement Award Recipient Dr. Ian C. Munro.

The meeting was called to order by Dr. Wilkinson as announced to all members and guests of the Society, at 10:00 a.m.

The Annual Business Meeting is an occasion for all members to participate to hear year-end reports and to vote on Council actions.

President Wilkinson opened the meeting by calling for approval of the minutes of the last meeting of November 7, 1997. By voice vote the minutes were approved as distributed.

He then presented his Annual Report (attached).

President Wilkinson introduced Dr. Ian C. Munro of CanTox Inc. of Ontario, Canada and he requested the Secretary to describe his long association with Dr. Munro that included his many years addressing food safety and environmental issues especially in the '70s, '80s, and '90s.

Dr. Carr pointed out a major reason for selecting Dr. Munro for the International Achievement Award was to recognize his guiding role as Chairman of the Expert Panel of Members of the excellent 1052 page RTP published Interpretive Review of Effects of Chlorinated Organic Chemicals. He concluded that his leadership and administrative skills were the source of the success of this encyclopedic report. Many important references have been made to this classic 1994 study as exhibited in our Journal.

Dr. Munro gave an address following the presentation of the Award by Dr. Wilkinson. He reviewed his present work on 1300 flavoring substances belonging to very simple chemical groups that have minor changes in chemical structure. There are only minor data on their toxicity and these findings may be different from the usual GRAS status of FDA adopted chemicals. A comprehensive report is under review.


Dr. Carr, Sallie W. Carr, and Dr. Keller gave their individual ISRTP Annual Business Meeting Reports for 1997. 


Dr. Giovacchini reported that he had explored various ways the Society might support educational internships or fellowships in the near future. Council discussed various steps the Society might take, e.g., partial financial support for graduate students, advisers to regulatory people regarding the scientific aspects of good data, and numerous similar projects. It was emphasized the Society needs to demonstrate that the organization is dedicated to promoting education and regulatory consensus based on sound science. These goals are clearly stated in our Brochure that develops ISRTP'S objectives, activities, membership openness and especially international educational activities.  

These aspects of ISRTP are significant in terms of potential requests by IRS that clearly recognize that funding of programs is an important part of our work and our records demonstrate this. Our Society is a 501(c)3 organization and non-profit and we have certain limitations that prevent our activities to influence political decisions.

Council debated these subjects at length, however, they were not able to agree upon a specific plan and Dr. Giovacchini was requested to continue his search.


Dr. Chaisson presented an outline of the present plans for the ISRTP Web Site. This will be completed by February 13, 1998.


Dr. Chaisson provided a general outline for a workshop entitled, "Probability and Distributional Risk Assessment: How Managers Use the New Risk Assessment Tools." The workshop had originally been planned for April 5-7, 1998, but because of the short time to finalize all arrangements with speakers and funding, the workshop will now be held August 16-19, 1998. This will give ample time to send out flyers and eventually a formal program brochure.


Dr. Keller reported that the Dourson meeting is on a hold. There is an agreement to follow-up on the NLM plan to attend a lecture at the Library. A future notice will provide the necessary information and date.

The planned meeting on Hormesis is under review and specific data will be forthcoming. Following the annual meeting Dr. Keller advised that the Hormesis meeting will be held in April, 1999. Plans are now under way to locate an appropriate meeting place in the Washington/Baltimore area.

ISRTP has agreed to provide $5,000 for the First International Symposium on "Role of Diet and Obesity in Aging, Cancer/Chronic Toxicology and Development" October 1998. The office of ISRTP is awaiting an invoice.

The meeting adjourned and the next Council meeting is scheduled for Monday March 16th in the office of Keller & Heckman. You may wish to mark your calendars that two additional dates for Council meetings have been selected -- May 11 and July 13.

Chris F. Wilkinson, President

The Society had a good year in 1997 and is in excellent standing in all respects. Our membership remains fairly constant at about 245 (we always seem to gain a few new members to replace the few who leave) and we have total financial assets of approximately $232,000 that will allow us to fund a variety of educational activities (fellowships or internships) in 1998. We are most grateful for the generous corporate support we continue to receive from a number of companies. Our Council meetings have been well attended and characterized by frank, open discussions of a wide variety of topics ranging from current regulatory and scientific issues worthy of a meeting to reevaluating the Mission of the Society and means by which we might update Society operations and improve membership interactions. I am sorry to report that Dr. George Cosmides has resigned from Council due to his move to California but pleased that his place has been taken by Dr. Michael Gough.

Before leaving Council, Dr. Cosmides prepared a detailed evaluation of the Society's Mission Statement and made several recommendations regarding how the Society might consider adapting to changing times, external competition and membership needs. This led to considerable introspective discussion and the formation of a Futures Planning Committee chaired by Dr. George Burdock that presented a draft modified Missions Statement and other recommendations to Council in October; these issues are still under active discussion and undoubtedly will lead to a few changes in 1998. Another major advance in the general organization of the Society is the development of an ISRTP Web Site. This is being developed by Dr. Christine Chaisson and her colleagues at TAS-ENVIRON and should be up and running early in 1998. It is anticipated that the Web Site will provide a valuable vehicle for improving communication and interaction among the membership of the Society and will be an excellent tool for promoting the Society's objectives to a much broader audience than is currently possible.

Our Journal, RTP, continues to be a major reason for the overall success of the Society and perhaps more than any other single factor reflects our primary objective of bringing sound science into the regulatory process. RTP continues to grow in popularity and to enhance the esteem of the Society and thanks to the tireless efforts of our Editor, Jeff Carr, over a hundred manuscripts have been processed during 1997. A steady stream of outstanding papers continues to be received and ensures the continuation and future success of RTP as the only journal covering the critical interface between science and the regulation. 

1997 has been a somewhat quieter-than-usual year for Society-sponsored Workshops and Symposia. The one meeting we did organize, "Assessing the Risks of Adverse Endocrine-Mediated Effects" held January 13-14 in Research Triangle Park, NC was, however, a huge success. We attracted an outstanding group of expert presenters from government, industry and academia and over 200 attendees participated in a series of panel discussions on critical endocrine-related topics. Several of the major presentations were published in RTP. We are looking forward to several Society-sponsored meetings in 1998 including one on "Probability and Distributional Risk Assessment" to be held April 5-7 in Washington, and others on "Chemical and Radiation Hormesis as a Biological Hypothesis" (organized by Ed Calabrese) and "Data-Derived Uncertainty Factors: Application to Non-Cancer and Cancer Risk Assessments" (organized by Mike Dourson). Another symposium with which the Society is involved entitled"Role of Diet and Obesity in Aging, Cancer/Chronic Toxicology and Development" will be held at the Lansdowne Conference Center and Resort in VA in the Fall of 1998.

This report would be incomplete without proper recognition of the enormous contributions of our Secretary and Executive Secretary, Jeff and Sallie Carr, to the day-to-day running of the Society. I have been truly amazed at the remarkable energy of Jeff and Sallie and their reliability in assuring that everything is done in a timely and friendly way even when, because of our own professional responsibilities, many of us are often forgetful and unresponsive. I want to thank them both most sincerely for their continued efforts on behalf of the Society.



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